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KMID : 0614620000360010039
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Korean Journal of Gastroenterology
2000 Volume.36 No. 1 p.39 ~ p.45
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Expression of the High Mobility Group 1 mRNA in Gastric Cancer
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Park Dong-Il
Son Hee-Jung
Song Sang-Yong
Sohn Tae-Sung
Kim Jae-Jun
Kim Young-Ho
Rhee Poong-Lyul
Koh Kwang-Cheol
Paik Seung-Woon
Rhee Jong-Chul
Choi Kyoo-Wan
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Abstract
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Background/Aims : High mobility group (HMG) proteins are nonhistone intranuclear architectural proteins involved in transcriptional regulation of gene. The purpose of this study was to investigate the role of HMG-1 protein expression in gastric cancer.
Methods : We obtained the biopsy specimens from 12 normal tissue, 14 patients with metaplastic gastritis, 14 patients with chronic atrophic gastritis, and 18 patients with gastric cancer. After performing comparative reverse transcription-polymerase chain reaction using GAPDH for these specimens, we analyzed the expression of HMG-1 mRNA semi-quantitatively. We investigated the relationship between the clinicopathologic findings and the level of HMG-1 mRNA expression in gastric cancer.
Results : The mean level of HMG-1/GAPDH ratio was 0.7±0.07 in normal tissue, 0.9± 0.13 in gastritis, and 1.6±0.40 in gastric cancer (p<0.05). There was no significant correlation between the levels of HMG-1 mRNA expression and several parameters such as age, gender, tumor size, depth of invasion, differentiation, Lauren’s classification, and
lymph node metastasis in gastric cancer.
Conclusions : The expression of HMG-1 mRNA was increased significantly in patients with gastric cancer. The function and the mechanism of HMG-1 protein in tumorigenesis and tumor differentiation are still unclear. Thus, further study is needed to elucidate the relationship between HMG-1 expression and tumorigenesis or tumor differentiation.
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KEYWORD
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High Mobility group (HMG)-1 단백, 위선암, High mobility group (HMG)-1 protein, Gastric cancer,
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